Nanne K H de Boer Selected Research

Thioguanine (Tioguanine)

11/2021	Advances in Thiopurine Drug Delivery: The Current State-of-the-Art.
1/2020	A comparative analysis of tioguanine versus low-dose thiopurines combined with allopurinol in inflammatory bowel disease patients.
6/2019	Limited relevance and progression of histological alterations in the liver during thioguanine therapy in inflammatory bowel disease patients.
1/2019	Sustained effectiveness, safety and therapeutic drug monitoring of tioguanine in a cohort of 274 IBD patients intolerant for conventional therapies.
1/2019	Systematic review with meta-analysis: risk factors for thiopurine-induced leukopenia in IBD.
1/2019	Clinical Course of Nodular Regenerative Hyperplasia in Thiopurine Treated Inflammatory Bowel Disease Patients.
12/2018	Patient-Reported Experiences with a Relicensed Generic: Thioguanine for the Treatment of Inflammatory Bowel Diseases.
10/2018	Biochemical efficacy of tioguanine in autoimmune hepatitis: a retrospective review of practice in the Netherlands.
4/2018	Thiopurines in Inflammatory Bowel Disease: New Findings and Perspectives.
1/2018	Methotrexate and Thioguanine Rescue Therapy for Conventional Thiopurine Failing Ulcerative Colitis Patients: A Multi-center Database Study on Tolerability and Effectiveness.

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Nanne K H de Boer Research Topics

Disease

46	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2022 - 04/2005
14	Crohn Disease (Crohn's Disease) 01/2022 - 11/2005
8	Ulcerative Colitis 05/2022 - 02/2011
7	Hyperplasia 06/2019 - 12/2007
6	Sepsis (Septicemia) 01/2022 - 01/2017
5	Infections 10/2020 - 06/2008
4	Adenoma (Adenomas) 01/2022 - 04/2013
3	Colitis 05/2022 - 01/2020
3	Leukemia 01/2022 - 12/2018
3	Colorectal Neoplasms (Colorectal Cancer) 01/2021 - 07/2014
3	Neoplasms (Cancer) 01/2020 - 01/2018
3	Leukopenia 01/2019 - 01/2009
3	Autoimmune Hepatitis 10/2018 - 04/2005
3	Gastrointestinal Diseases (Functional Gastrointestinal Disorders) 01/2018 - 07/2014
2	Fistula 11/2021 - 08/2015
2	Autoimmune Diseases (Autoimmune Disease) 11/2021 - 06/2006
2	Severe Acute Malnutrition 02/2021 - 11/2020
2	Necrosis 01/2020 - 07/2017
2	Portal Hypertension 01/2019 - 01/2019
2	Necrotizing Enterocolitis 09/2015 - 02/2015
2	Pancytopenia 03/2014 - 06/2008
1	Hereditary Nonpolyposis Colorectal Neoplasms (Hereditary Nonpolyposis Colorectal Cancer) 01/2022
1	Systemic Lupus Erythematosus (Libman-Sacks Disease) 11/2021
1	Patent Ductus Arteriosus 02/2021
1	Carcinoma (Carcinomatosis) 01/2020
1	Rectal Fistula (Anal Fistula) 01/2020
1	Disease Progression 01/2019
1	Nephrolithiasis 01/2019
1	Kidney Calculi (Kidney Stone) 10/2018
1	Gout 10/2018
1	Uterine Cervical Neoplasms (Cancer of the Cervix) 01/2018
1	Bronchopulmonary Dysplasia 01/2018
1	Liver Cirrhosis (Hepatic Cirrhosis) 01/2018
1	Fibrosis (Cirrhosis) 01/2018
1	Spontaneous Abortion (Miscarriage) 08/2017
1	Chronic Disease (Chronic Diseases) 08/2017
1	Birth Weight (Birth Weights) 08/2017
1	Pregnancy Complications 08/2017
1	Congenital Abnormalities (Deformity) 08/2017
1	Stillbirth 08/2017
1	Hypersensitivity (Allergy) 08/2017
1	Anemia 06/2017
1	Thrombocytopenia (Thrombopenia) 06/2017
1	Inflammation (Inflammations) 12/2016
1	Liver Diseases (Liver Disease) 01/2016
1	Intestinal Diseases (Diseases, Intestinal) 09/2014
1	Pre-Eclampsia (Preeclampsia) 03/2014

Drug/Important Bio-Agent (IBA)

31	2-mercaptopurineIBA 01/2022 - 11/2005
21	Thioguanine (Tioguanine)FDA Link 11/2021 - 04/2005
19	Azathioprine (Imuran)FDA LinkGeneric 01/2022 - 04/2005
16	Volatile Organic CompoundsIBA 01/2022 - 07/2014
16	Mercaptopurine (6 Mercaptopurine)FDA LinkGeneric 01/2022 - 04/2005
9	Allopurinol (Remid)FDA LinkGeneric 01/2022 - 04/2011
9	Biomarkers (Surrogate Marker)IBA 01/2022 - 09/2014
8	Pharmaceutical PreparationsIBA 01/2022 - 04/2005
7	Adrenal Cortex Hormones (Corticosteroids)IBA 05/2022 - 04/2005
5	Leukocyte L1 Antigen Complex (Calgranulin)IBA 05/2022 - 01/2018
4	C-Reactive ProteinIBA 05/2022 - 01/2018
4	vedolizumabIBA 05/2022 - 01/2020
4	Ustekinumab (CNTO 1275)FDA Link 11/2021 - 01/2020
4	Immunosuppressive Agents (Immunosuppressants)IBA 01/2020 - 06/2013
3	Amino Acids FDA Link 01/2022 - 01/2018
3	Methotrexate (Mexate)FDA LinkGeneric 01/2018 - 11/2005
2	tofacitinibIBA 05/2022 - 01/2020
2	Janus Kinase InhibitorsIBA 05/2022 - 01/2020
2	NucleotidesIBA 01/2019 - 12/2007
2	thiopurine methyltransferase (thiopurine S-methyltransferase)IBA 01/2009 - 06/2008
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 05/2022
1	Delayed-Action PreparationsIBA 11/2021
1	Ibuprofen (Motrin)FDA LinkGeneric 02/2021
1	Bicarbonates (Hydrogen Carbonate)IBA 02/2021
1	DNA (Deoxyribonucleic Acid)IBA 01/2020
1	LipidsIBA 01/2020
1	Matrix Metalloproteinases (MMPs)IBA 01/2019
1	Mesalamine (Mesalazine)FDA LinkGeneric 01/2019
1	6-methylthiopurineIBA 01/2019
1	Generic DrugsIBA 12/2018
1	SteroidsIBA 10/2018
1	Immunomodulating AgentsIBA 04/2018
1	SmokeIBA 01/2018
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2018
1	Hemoglobins (Hemoglobin)IBA 06/2017
1	Carrier Proteins (Binding Protein)IBA 12/2016
1	Proteins (Proteins, Gene)FDA Link 12/2016
1	Monomeric GTP-Binding ProteinsIBA 12/2016
1	triphosphoric acid (triphosphate)IBA 12/2016
1	Essential DrugsIBA 11/2016
1	IpilimumabIBA 12/2014
1	Alkaline PhosphataseIBA 03/2014

Therapy/Procedure

32	Therapeutics 01/2022 - 04/2005
4	Electronic Nose 01/2018 - 07/2014
1	Central Venous Catheters 01/2020
1	Hyperbaric Oxygenation 01/2020
1	Off-Label Use 01/2020
1	Catheters 01/2020
1	Esophagectomy 01/2019
1	Pancreaticoduodenectomy 01/2019
1	Duration of Therapy 01/2019
1	Immunomodulation 01/2017
1	Combined Modality Therapy 08/2015